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The Annihilation of Mankind is a prophesied event, written and described in books like the "Rattlebeani Intervention" and "I Will Be Called Poop" It describes an event where during a science experiment some 150 years into the future, that Francis will split all his variants that he plays as, and they will be cloned as independently functioning beings. Its noted that Darth Francis, Fiendcis, and Clowncis will not survive this splitting process, but Pope Trancis would, being in a terribly mortally wounded state.
Upon being taken to the hospital, he was put into a robot suit running a future version of UncleFree.Exe, however he'd be infected with a virus and turn evil. Escaping from the hospital, he would travel across Europe enacting a mass genocide on all straight men, and is estimated to kill off 60% of the European population singe handily through a systematic genocide.
It's said he will be shut down eventually, but reactivated after Demarions pontificate, possibly being connected to Dimonds Endtimes prophecy where he will slaughter every single person left in the world, or get close to it, however this is not included in Dimonds main prophecy, nor Michael Dimonds commentaries on the prophecy.